FINHUB Insights

What the executives and directors of Vertex Pharmaceuticals actually did with their own shares, decoded from three years of SEC Form 4 filings.

−$152.6M net open-market flow, 12 m
4 open-market buys, 12 m
100% of sale value on 10b5-1 plans
365 days since an insider bought

The tape: three years of insider trades

Open-market buy Discretionary sale Planned sale (10b5-1) Reported-price path Routine
$200$4002024Jul2025Jul2026JulKearney Terrence C — routine flow, 10K (2023-08-10)Biller Jonathan — routine flow, 408 (2023-09-29)Lagarde Michel — routine flow, 1,132 (2023-10-05)SACHS BRUCE I — routine flow, 11.3K (2023-11-06)Thornberry Nancy — routine flow, 1,136 (2023-12-05)Arbuckle Stuart A — routine flow, 8,603 (2023-12-13)Kewalramani Reshma — routine flow, 17.1K (2023-12-15)WAGNER CHARLES F JR — routine flow, 25K (2024-02-09)LEIDEN JEFFREY M — routine flow, 49.4K (2024-02-09)Sachdev Amit — routine flow, 22.8K (2024-02-09)ALTSHULER DAVID — routine flow, 22.9K (2024-02-09)Arbuckle Stuart A — routine flow, 29.8K (2024-02-09)Kewalramani Reshma — routine flow, 70.1K (2024-02-09)Biller Jonathan — routine flow, 12.6K (2024-02-09)Tatsis Ourania — routine flow, 24.1K (2024-02-09)Bozic Carmen — routine flow, 21.7K (2024-02-09)Ambrose Kristen — routine flow, 5,394 (2024-02-09)Atkinson Edward Morrow III — routine flow, 11.8K (2024-02-09)WAGNER CHARLES F JR — routine flow, 3,750 (2024-02-16)Sachdev Amit — routine flow, 3,498 (2024-02-16)ALTSHULER DAVID — routine flow, 3,750 (2024-02-16)Arbuckle Stuart A — routine flow, 4,499 (2024-02-16)Kewalramani Reshma — routine flow, 9,359 (2024-02-16)Tatsis Ourania — routine flow, 4,499 (2024-02-16)Bozic Carmen — routine flow, 3,750 (2024-02-16)Atkinson Edward Morrow III — routine flow, 1,501 (2024-02-16)LEIDEN JEFFREY M — routine flow, 4,118 (2024-02-20)WAGNER CHARLES F JR — routine flow, 6,121 (2024-02-23)Sachdev Amit — routine flow, 5,092 (2024-02-23)ALTSHULER DAVID — routine flow, 6,782 (2024-02-23)Arbuckle Stuart A — routine flow, 8,087 (2024-02-23)Kewalramani Reshma — routine flow, 16.4K (2024-02-23)Tatsis Ourania — routine flow, 6,682 (2024-02-23)Bozic Carmen — routine flow, 6,121 (2024-02-23)Atkinson Edward Morrow III — routine flow, 2,779 (2024-02-23)Ambrose Kristen — routine flow, 828 (2024-02-23)Ambrose Kristen — routine flow, 225 (2024-04-01)CARNEY LLOYD — routine flow, 1,001 (2024-05-01)Upadhyay Suketu — routine flow, 1,001 (2024-05-01)Bhatia Sangeeta N. — routine flow, 1,001 (2024-05-01)MCKENZIE DIANA — routine flow, 1,001 (2024-05-01)Thornberry Nancy — routine flow, 501 (2024-05-01)Atkinson Edward Morrow III — routine flow, 14.1K (2024-05-14)Schneider Jennifer — routine flow, 922 (2024-05-15)SACHS BRUCE I — routine flow, 7,073 (2024-05-22)Kewalramani Reshma — routine flow, 1,565 (2024-05-24)Sachdev Amit — routine flow, 4,600 (2024-06-05)Atkinson Edward Morrow III — routine flow, 6,824 (2024-06-11)SACHS BRUCE I — routine flow, 5,295 (2024-08-01)Bhatia Sangeeta N. — routine flow, 1,292 (2024-08-08)Bhatia Sangeeta N. — routine flow, 646 (2024-08-30)Biller Jonathan — routine flow, 630 (2024-10-01)WAGNER CHARLES F JR — routine flow, 17.4K (2025-02-04)LEIDEN JEFFREY M — routine flow, 15.4K (2025-02-04)Sachdev Amit — routine flow, 15.3K (2025-02-04)ALTSHULER DAVID — routine flow, 19.4K (2025-02-04)Arbuckle Stuart A — routine flow, 23.1K (2025-02-04)Kewalramani Reshma — routine flow, 49.4K (2025-02-04)Biller Jonathan — routine flow, 4,744 (2025-02-04)Tatsis Ourania — routine flow, 17.4K (2025-02-04)Bozic Carmen — routine flow, 16.2K (2025-02-04)Ambrose Kristen — routine flow, 4,420 (2025-02-04)Atkinson Edward Morrow III — routine flow, 9,876 (2025-02-04)WAGNER CHARLES F JR — routine flow, 11.6K (2025-02-14)Sachdev Amit — routine flow, 10.4K (2025-02-14)ALTSHULER DAVID — routine flow, 9,759 (2025-02-14)Arbuckle Stuart A — routine flow, 13.8K (2025-02-14)Kewalramani Reshma — routine flow, 33.9K (2025-02-14)Biller Jonathan — routine flow, 7,573 (2025-02-14)Tatsis Ourania — routine flow, 10.6K (2025-02-14)Bozic Carmen — routine flow, 9,600 (2025-02-14)Ambrose Kristen — routine flow, 3,235 (2025-02-14)Atkinson Edward Morrow III — routine flow, 8,616 (2025-02-14)LEIDEN JEFFREY M — routine flow, 15.8K (2025-02-14)WAGNER CHARLES F JR — routine flow, 8,272 (2025-02-26)Sachdev Amit — routine flow, 6,173 (2025-02-26)ALTSHULER DAVID — routine flow, 9,925 (2025-02-26)Arbuckle Stuart A — routine flow, 11.8K (2025-02-26)Kewalramani Reshma — routine flow, 23.5K (2025-02-26)Tatsis Ourania — routine flow, 8,272 (2025-02-26)Bozic Carmen — routine flow, 8,272 (2025-02-26)Ambrose Kristen — routine flow, 2,069 (2025-02-26)Atkinson Edward Morrow III — routine flow, 4,138 (2025-02-26)CARNEY LLOYD — routine flow, 796 (2025-05-01)Garber Alan M — routine flow, 398 (2025-05-01)Upadhyay Suketu — routine flow, 796 (2025-05-01)Bhatia Sangeeta N. — routine flow, 796 (2025-05-01)MCKENZIE DIANA — routine flow, 796 (2025-05-01)Schneider Jennifer — routine flow, 796 (2025-05-01)Thornberry Nancy — routine flow, 398 (2025-05-01)Arbuckle Stuart A — routine flow, 37.6K (2025-05-13)Arbuckle Stuart A — routine flow, 37.2K (2025-07-01)Biller Jonathan — routine flow, 1,259 (2025-10-01)LEIDEN JEFFREY M — routine flow, 73.3K (2025-11-14)CARNEY LLOYD — routine flow, 800 (2025-11-19)LEIDEN JEFFREY M — routine flow, 63.8K (2025-12-04)WAGNER CHARLES F JR — routine flow, 9,532 (2026-01-06)WAGNER CHARLES F JR — routine flow, 13.6K (2026-01-22)LEIDEN JEFFREY M — routine flow, 9,012 (2026-01-22)Sachdev Amit — routine flow, 11.7K (2026-01-22)ALTSHULER DAVID — routine flow, 11.2K (2026-01-22)Kewalramani Reshma — routine flow, 38.9K (2026-01-22)Biller Jonathan — routine flow, 9,068 (2026-01-22)Tatsis Ourania — routine flow, 11.7K (2026-01-22)Bozic Carmen — routine flow, 11.3K (2026-01-22)Ambrose Kristen — routine flow, 4,250 (2026-01-22)Atkinson Edward Morrow III — routine flow, 7,817 (2026-01-22)McKechnie Duncan — routine flow, 6,800 (2026-01-22)WAGNER CHARLES F JR — routine flow, 7,610 (2026-02-13)Sachdev Amit — routine flow, 5,605 (2026-02-13)Kewalramani Reshma — routine flow, 21.3K (2026-02-13)Biller Jonathan — routine flow, 4,623 (2026-02-13)Tatsis Ourania — routine flow, 5,944 (2026-02-13)Bozic Carmen — routine flow, 5,949 (2026-02-13)Ambrose Kristen — routine flow, 1,985 (2026-02-13)Atkinson Edward Morrow III — routine flow, 2,775 (2026-02-13)McKechnie Duncan — routine flow, 3,410 (2026-02-13)Bunnage Mark E. — routine flow, 3,410 (2026-02-13)WAGNER CHARLES F JR — routine flow, 9,659 (2026-02-17)Kewalramani Reshma — routine flow, 22.9K (2026-02-17)Biller Jonathan — routine flow, 5,640 (2026-02-17)Tatsis Ourania — routine flow, 8,083 (2026-02-17)Bozic Carmen — routine flow, 7,287 (2026-02-17)Ambrose Kristen — routine flow, 2,407 (2026-02-17)Atkinson Edward Morrow III — routine flow, 6,492 (2026-02-17)McKechnie Duncan — routine flow, 6,110 (2026-02-17)Bunnage Mark E. — routine flow, 3,694 (2026-02-17)LEIDEN JEFFREY M — routine flow, 11.2K (2026-02-18)Sachdev Amit — routine flow, 56.4K (2026-02-19)WAGNER CHARLES F JR — routine flow, 1,744 (2026-02-24)LEIDEN JEFFREY M — routine flow, 3,547 (2026-02-24)Sachdev Amit — routine flow, 1,518 (2026-02-24)Kewalramani Reshma — routine flow, 4,981 (2026-02-24)Biller Jonathan — routine flow, 1,144 (2026-02-24)Tatsis Ourania — routine flow, 1,627 (2026-02-24)Bozic Carmen — routine flow, 1,453 (2026-02-24)Ambrose Kristen — routine flow, 546 (2026-02-24)Atkinson Edward Morrow III — routine flow, 1,627 (2026-02-24)McKechnie Duncan — routine flow, 873 (2026-02-24)Bunnage Mark E. — routine flow, 582 (2026-02-24)Garber Alan M — routine flow, 472 (2026-05-01)Bhatia Sangeeta N. — routine flow, 943 (2026-05-01)MCKENZIE DIANA — routine flow, 943 (2026-05-01)Schneider Jennifer — routine flow, 472 (2026-05-01)Thornberry Nancy — routine flow, 472 (2026-05-01)Sachdev Amit — routine flow, 8,251 (2026-07-21)Tatsis Ourania — routine flow, 8,251 (2026-07-21)Routine: vests, tax, giftsTatsis Ourania (Officer) — Planned sale (10b5-1): 2,500 @ $355 = $888K (2023-08-23)Bozic Carmen (Officer) — Planned sale (10b5-1): 5,651 @ $352.66 = $2M (2023-09-05)Bozic Carmen (Officer) — Planned sale (10b5-1): 5,651 @ $351 = $2M (2023-09-19)Biller Jonathan (Officer) — Planned sale (10b5-1): 610 @ $346.76 = $212K (2023-10-02)Bozic Carmen (Officer) — Planned sale (10b5-1): 5,651 @ $345.28 = $2M (2023-10-03)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 242 @ $360 = $87K (2023-10-06)LEIDEN JEFFREY M (Officer) — Planned sale (10b5-1): 13K @ $374 = $4.8M (2023-10-16)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 243 @ $375 = $91K (2023-10-17)Bozic Carmen (Officer) — Planned sale (10b5-1): 5,651 @ $373.25 = $2.1M (2023-10-17)Bozic Carmen (Officer) — Planned sale (10b5-1): 5,651 @ $355.92 = $2M (2023-10-31)SACHS BRUCE I (Director) — Planned sale (10b5-1): 11.3K @ $385 = $4.3M (2023-11-06)Kewalramani Reshma (CEO) — Planned sale (10b5-1): 5,097 @ $377 = $1.9M (2023-11-13)Bozic Carmen (Officer) — Planned sale (10b5-1): 5,650 @ $380.82 = $2.2M (2023-11-14)Sachdev Amit (Officer) — Planned sale (10b5-1): 35 @ $369.92 = $13K (2023-11-15)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 19 @ $369.92 = $7K (2023-11-15)WAGNER CHARLES F JR (CFO) — Planned sale (10b5-1): 3,000 @ $349.88 = $1M (2023-11-20)LEIDEN JEFFREY M (Officer) — Planned sale (10b5-1): 13.4K @ $399.42 = $5.3M (2023-12-13)Arbuckle Stuart A (COO) — Planned sale (10b5-1): 8,603 @ $399 = $3.4M (2023-12-13)Kewalramani Reshma (CEO) — Planned sale (10b5-1): 22.2K @ $404.71 = $9M (2023-12-15)WAGNER CHARLES F JR (CFO) — Planned sale (10b5-1): 3,000 @ $405 = $1.2M (2024-01-02)LEIDEN JEFFREY M (Officer) — Planned sale (10b5-1): 6,648 @ $419.07 = $2.8M (2024-01-08)Sachdev Amit (Officer) — Planned sale (10b5-1): 3,222 @ $420.24 = $1.4M (2024-02-12)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 3,145 @ $420.24 = $1.3M (2024-02-12)Arbuckle Stuart A (COO) — Planned sale (10b5-1): 4,295 @ $420.24 = $1.8M (2024-02-12)Biller Jonathan (Officer) — Planned sale (10b5-1): 1,738 @ $418.77 = $728K (2024-02-12)Tatsis Ourania (Officer) — Planned sale (10b5-1): 314 @ $420.24 = $132K (2024-02-12)Ambrose Kristen (Officer) — Planned sale (10b5-1): 1,374 @ $420.24 = $577K (2024-02-12)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 913 @ $420.24 = $384K (2024-02-12)LEIDEN JEFFREY M (Officer) — Planned sale (10b5-1): 12.4K @ $419.19 = $5.2M (2024-02-15)Sachdev Amit (Officer) — Planned sale (10b5-1): 7,445 @ $421.21 = $3.1M (2024-02-21)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 7,004 @ $421.21 = $3M (2024-02-21)Arbuckle Stuart A (COO) — Planned sale (10b5-1): 8,407 @ $421.21 = $3.5M (2024-02-21)Tatsis Ourania (Officer) — Planned sale (10b5-1): 840 @ $421.21 = $354K (2024-02-21)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 2,002 @ $421.38 = $844K (2024-02-21)Sachdev Amit (Officer) — Planned sale (10b5-1): 3,004 @ $425.7 = $1.3M (2024-02-26)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 4,239 @ $425.7 = $1.8M (2024-02-26)Arbuckle Stuart A (COO) — Planned sale (10b5-1): 5,034 @ $425.7 = $2.1M (2024-02-26)Tatsis Ourania (Officer) — Planned sale (10b5-1): 354 @ $425.7 = $151K (2024-02-26)Ambrose Kristen (Officer) — Planned sale (10b5-1): 883 @ $425.7 = $376K (2024-02-26)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 883 @ $425.7 = $376K (2024-02-26)Ambrose Kristen (Officer) — Planned sale (10b5-1): 240 @ $419 = $101K (2024-04-02)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 467 @ $402.95 = $188K (2024-05-02)Sachdev Amit (Officer) — Planned sale (10b5-1): 32 @ $430.93 = $14K (2024-05-15)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 54 @ $430.93 = $23K (2024-05-15)Arbuckle Stuart A (COO) — Planned sale (10b5-1): 69 @ $430.93 = $30K (2024-05-15)SACHS BRUCE I (Director) — Planned sale (10b5-1): 7,073 @ $448 = $3.2M (2024-05-22)Kewalramani Reshma (CEO) — Planned sale (10b5-1): 16.8K @ $447.93 = $7.5M (2024-05-24)WAGNER CHARLES F JR (CFO) — Planned sale (10b5-1): 3,250 @ $454.79 = $1.5M (2024-05-28)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,280 @ $445.56 = $1M (2024-05-29)Tatsis Ourania (Officer) — Planned sale (10b5-1): 4,600 @ $441.99 = $2M (2024-05-31)WAGNER CHARLES F JR (CFO) — Planned sale (10b5-1): 3,250 @ $460 = $1.5M (2024-06-03)Tatsis Ourania (Officer) — Planned sale (10b5-1): 2,175 @ $460 = $1M (2024-06-03)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,280 @ $478 = $1.1M (2024-06-12)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 7,288 @ $478 = $3.5M (2024-06-12)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,280 @ $471.72 = $1.1M (2024-06-26)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,280 @ $487.34 = $1.1M (2024-07-10)Kewalramani Reshma (CEO) — Planned sale (10b5-1): 15.2K @ $497 = $7.6M (2024-07-22)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,280 @ $488.46 = $1.1M (2024-07-24)Kewalramani Reshma (CEO) — Planned sale (10b5-1): 15.2K @ $505 = $7.7M (2024-07-30)SACHS BRUCE I (Director) — Planned sale (10b5-1): 5,295 @ $508 = $2.7M (2024-08-01)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,280 @ $476.75 = $1.1M (2024-08-07)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 1,292 @ $466.29 = $602K (2024-08-08)LEIDEN JEFFREY M (Officer) — Planned sale (10b5-1): 3,784 @ $499 = $1.9M (2024-08-30)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 646 @ $500 = $323K (2024-08-30)Biller Jonathan (Officer) — Planned sale (10b5-1): 999 @ $461.66 = $461K (2024-10-02)Kewalramani Reshma (CEO) — Planned sale (10b5-1): 15.2K @ $515 = $7.8M (2024-11-08)WAGNER CHARLES F JR (CFO) — Planned sale (10b5-1): 3,000 @ $518.27 = $1.6M (2024-11-11)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 15 @ $478.56 = $7K (2024-11-15)Biller Jonathan (Officer) — Planned sale (10b5-1): 3,433 @ $459.87 = $1.6M (2025-02-11)Tatsis Ourania (Officer) — Planned sale (10b5-1): 310 @ $459.83 = $143K (2025-02-11)Ambrose Kristen (Officer) — Planned sale (10b5-1): 1,376 @ $459.83 = $633K (2025-02-11)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 1,747 @ $459.83 = $803K (2025-02-11)Biller Jonathan (Officer) — Planned sale (10b5-1): 1,657 @ $455.06 = $754K (2025-02-18)Tatsis Ourania (Officer) — Planned sale (10b5-1): 244 @ $455.06 = $111K (2025-02-18)Ambrose Kristen (Officer) — Planned sale (10b5-1): 671 @ $455.06 = $305K (2025-02-18)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 1,111 @ $480 = $533K (2025-02-20)Ambrose Kristen (Officer) — Planned sale (10b5-1): 884 @ $480.95 = $425K (2025-02-25)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 2,120 @ $480.38 = $1M (2025-02-27)Tatsis Ourania (Officer) — Planned sale (10b5-1): 884 @ $477.59 = $422K (2025-02-27)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 4,417 @ $477.58 = $2.1M (2025-02-27)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 3,231 @ $490 = $1.6M (2025-03-03)Tatsis Ourania (Officer) — Planned sale (10b5-1): 4,058 @ $485.49 = $2M (2025-03-04)WAGNER CHARLES F JR (CFO) — Planned sale (10b5-1): 3,298 @ $500 = $1.6M (2025-03-10)Tatsis Ourania (Officer) — Planned sale (10b5-1): 3,242 @ $499.99 = $1.6M (2025-03-10)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 6,462 @ $505 = $3.3M (2025-03-13)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 400 @ $505.86 = $202K (2025-05-02)ALTSHULER DAVID (Officer) — Planned sale (10b5-1): 52 @ $424.69 = $22K (2025-05-15)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 266 @ $386.69 = $103K (2025-08-27)Biller Jonathan (Officer) — Planned sale (10b5-1): 694 @ $404.21 = $281K (2025-10-02)LEIDEN JEFFREY M (Officer) — Planned sale (10b5-1): 73.3K @ $440.6 = $32.3M (2025-11-14)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 2,500 @ $434.58 = $1.1M (2025-11-17)WAGNER CHARLES F JR (Officer) — Planned sale (10b5-1): 14K @ $456 = $6.4M (2025-12-03)LEIDEN JEFFREY M (Officer) — Planned sale (10b5-1): 63.8K @ $449.2 = $28.7M (2025-12-03)Biller Jonathan (Officer) — Planned sale (10b5-1): 347 @ $449 = $156K (2025-12-03)Tatsis Ourania (Officer) — Planned sale (10b5-1): 4,500 @ $449.99 = $2M (2025-12-03)WAGNER CHARLES F JR (Officer) — Planned sale (10b5-1): 9,532 @ $461 = $4.4M (2026-01-06)Tatsis Ourania (Officer) — Planned sale (10b5-1): 4,500 @ $474.99 = $2.1M (2026-01-07)Ambrose Kristen (Officer) — Planned sale (10b5-1): 1,376 @ $460.43 = $634K (2026-02-11)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 1,751 @ $460.43 = $806K (2026-02-11)Bunnage Mark E. (Officer) — Planned sale (10b5-1): 2,021 @ $460.43 = $931K (2026-02-11)Biller Jonathan (Officer) — Planned sale (10b5-1): 2,913 @ $473.51 = $1.4M (2026-02-13)Tatsis Ourania (Officer) — Planned sale (10b5-1): 1,966 @ $490.61 = $965K (2026-02-13)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 266 @ $500 = $133K (2026-02-13)Biller Jonathan (Officer) — Planned sale (10b5-1): 3,720 @ $484.18 = $1.8M (2026-02-18)Tatsis Ourania (Officer) — Planned sale (10b5-1): 977 @ $483.52 = $472K (2026-02-18)Ambrose Kristen (Officer) — Planned sale (10b5-1): 2,195 @ $484.87 = $1.1M (2026-02-18)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 2,848 @ $484.93 = $1.4M (2026-02-18)Bunnage Mark E. (Officer) — Planned sale (10b5-1): 3,619 @ $484.31 = $1.8M (2026-02-18)Sachdev Amit (Officer) — Planned sale (10b5-1): 58.6K @ $468.83 = $27.5M (2026-02-19)Sachdev Amit (Officer) — Planned sale (10b5-1): 1,846 @ $486.35 = $898K (2026-02-25)Biller Jonathan (Officer) — Planned sale (10b5-1): 945 @ $486.35 = $460K (2026-02-25)Tatsis Ourania (Officer) — Planned sale (10b5-1): 260 @ $486.35 = $126K (2026-02-25)Atkinson Edward Morrow III (Officer) — Planned sale (10b5-1): 668 @ $486.35 = $325K (2026-02-25)McKechnie Duncan (Officer) — Planned sale (10b5-1): 4,910 @ $487.65 = $2.4M (2026-02-25)Bunnage Mark E. (Officer) — Planned sale (10b5-1): 620 @ $486.35 = $302K (2026-02-25)Ambrose Kristen (Officer) — Planned sale (10b5-1): 580 @ $484.51 = $281K (2026-02-26)Kewalramani Reshma (CEO) — Planned sale (10b5-1): 40K @ $493.47 = $19.7M (2026-02-27)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,329 @ $480.31 = $1.1M (2026-02-27)Liu Joy (Officer) — Planned sale (10b5-1): 892 @ $495.96 = $442K (2026-03-02)McKechnie Duncan (Officer) — Planned sale (10b5-1): 2,437 @ $475.3 = $1.2M (2026-03-04)McKechnie Duncan (Officer) — Planned sale (10b5-1): 2,633 @ $498.42 = $1.3M (2026-03-11)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,329 @ $481.79 = $1.1M (2026-03-13)Bozic Carmen (Officer) — Planned sale (10b5-1): 2,329 @ $450.95 = $1.1M (2026-03-27)Liu Joy (Officer) — Planned sale (10b5-1): 978 @ $449.17 = $439K (2026-04-01)Liu Joy (Officer) — Planned sale (10b5-1): 1,104 @ $425.02 = $469K (2026-05-01)Bhatia Sangeeta N. (Director) — Planned sale (10b5-1): 318 @ $423.73 = $135K (2026-05-04)Bozic Carmen (Officer) — Planned sale (10b5-1): 8,342 @ $450.56 = $3.8M (2026-05-15)Bunnage Mark E. (Officer) — Planned sale (10b5-1): 33 @ $453.45 = $15K (2026-05-15)Bozic Carmen (Officer) — Planned sale (10b5-1): 1,974 @ $450 = $888K (2026-05-29)Liu Joy (Officer) — Planned sale (10b5-1): 828 @ $439.91 = $364K (2026-06-01)Bozic Carmen (Officer) — Planned sale (10b5-1): 1,745 @ $450 = $785K (2026-06-05)Bozic Carmen (Officer) — Planned sale (10b5-1): 5,082 @ $452.44 = $2.3M (2026-06-18)Bozic Carmen (Officer) — Planned sale (10b5-1): 596 @ $482.5 = $288K (2026-06-26)Liu Joy (Officer) — Planned sale (10b5-1): 828 @ $502.71 = $416K (2026-07-01)Tatsis Ourania (Officer) — Planned sale (10b5-1): 1,500 @ $524.99 = $787K (2026-07-02)McKechnie Duncan (Officer) — Planned sale (10b5-1): 1,541 @ $519 = $800K (2026-07-02)SACHS BRUCE I (Director) — Open-market buy: 5,000 @ $389.68 = $1.9M (2025-08-06)Kewalramani Reshma (CEO) — Open-market buy: 10K @ $389.58 = $3.9M (2025-08-06)Kewalramani $3.9MSachs $1.9M

Every marker sits at the exact price reported on the Form 4. The line is the monthly median of all prices insiders reported, so the chart needs no market feed; the gray strip is routine flow (vestings, tax withholding, gifts) that headlines love to miscount as selling.

Where the shares went, last 12 months

From holdings: 21.8KFrom holdings 21.8KGranted: 222.6KGranted 222.6KVested / exercised: 195.1KVested / exercised 195.1KBought on market: 15KBought on market 15KWithheld for tax: 110.4KWithheld for tax 110.4KPlanned sales (10b5-1): 343.3KPlanned sales (10b5-1) 343.3KGifts: 800Gifts 800

Every Form 4 movement decomposed: what flowed in (grants, vested equity, purchases) and what flowed out (tax withholding, plan sales, discretionary sales, gifts). Counted in shares, because grants carry no price.

Skin in the game

10020222023202420252026WAGNER CHARLES F JRTatsis OuraniaArbuckle Stuart ASachdev AmitKewalramani ReshmaSachdev 208.3Arbuckle 154.2Kewalramani 133.3Tatsis 90.4Wagner 77.9

Directly held shares as reported after each trade, indexed to 100 five years back. Direct holdings only: trust and family-entity positions are per-entity in the filings and do not sum honestly, so this chart refuses to guess. The steps are the trades.

Who holds what

Insider Role Shares held Buys 12 m Sales 12 m 12 m Last trade
Kewalramani Reshma CEO & President CEO 137.9K $3.9M $19.7M 2026-02-27
Sachdev Amit EVP Chief Patient & Ext Af Off Officer 66.5K $28.4M 2026-02-25
Arbuckle Stuart A EVP, COO COO 63.4K 2024-05-15
Tatsis Ourania EVP, Chief Reg. & Quality Off. Officer 53.6K $6.5M 2026-07-02
WAGNER CHARLES F JR EVP, CO & FO Officer 47K $10.8M 2026-01-06
SACHS BRUCE I Director 41.6K $1.9M 2025-08-06
LEIDEN JEFFREY M Executive Chairman Officer 34.8K $60.9M 2025-12-03
ALTSHULER DAVID EVP, Chief Scientific Officer Officer 31.1K 2025-05-15
Liu Joy EVP and Chief Legal Officer Officer 19.1K $2.1M 2026-07-01
Atkinson Edward Morrow III EVP, Chief Technical Ops. Off. Officer 18.4K $3.6M 2026-02-25
Kearney Terrence C Director 16.5K 2023-08-10
Bozic Carmen EVP and CMO Officer 15.3K $11.3M 2026-06-26
Biller Jonathan EVP and Chief Legal Officer Officer 13.7K $4.1M 2026-02-25
McKechnie Duncan EVP, Chief Commercial Officer Officer 11K $5.7M 2026-07-02

Open-market trade log

Date Insider Type Shares Price Value Since trade Filed
2026-07-02 Tatsis Ourania (Officer) Planned sale (10b5-1) 1,500 $524.99 $787K -1.1% 2026-07-07
2026-07-02 McKechnie Duncan (Officer) Planned sale (10b5-1) 1,541 $519.00 $800K 0% 2026-07-07
2026-07-01 Liu Joy (Officer) Planned sale (10b5-1) 828 $502.71 $416K +3.2% 2026-07-06
2026-06-26 Bozic Carmen (Officer) Planned sale (10b5-1) 596 $482.50 $288K +7.6% 2026-06-30
2026-06-18 Bozic Carmen (Officer) Planned sale (10b5-1) 1,020 $462.17 $471K +12.3% 2026-06-23
2026-06-15 Bozic Carmen (Officer) Planned sale (10b5-1) 4,062 $450.00 $1.8M +15.3% 2026-06-17
2026-06-05 Bozic Carmen (Officer) Planned sale (10b5-1) 1,745 $450.00 $785K +15.3% 2026-06-09
2026-06-01 Liu Joy (Officer) Planned sale (10b5-1) 828 $439.91 $364K +18% 2026-06-03
2026-05-29 Bozic Carmen (Officer) Planned sale (10b5-1) 1,974 $450.00 $888K +15.3% 2026-06-02
2026-05-15 Bozic Carmen (Officer) Planned sale (10b5-1) 1,354 $453.45 $614K +14.5% 2026-05-19
2026-05-15 Bunnage Mark E. (Officer) Planned sale (10b5-1) 33 $453.45 $15K +14.5% 2026-05-19
2026-05-12 Bozic Carmen (Officer) Planned sale (10b5-1) 6,988 $450.00 $3.1M +15.3% 2026-05-14
2026-05-04 Bhatia Sangeeta N. (Director) Planned sale (10b5-1) 318 $423.73 $135K +22.5% 2026-05-05
2026-05-01 Liu Joy (Officer) Planned sale (10b5-1) 1,104 $425.02 $469K +22.1% 2026-05-05
2026-04-01 Liu Joy (Officer) Planned sale (10b5-1) 978 $449.17 $439K +15.6% 2026-04-03
2026-03-27 Bozic Carmen (Officer) Planned sale (10b5-1) 2,329 $450.95 $1.1M +15.1% 2026-03-31
2026-03-13 Bozic Carmen (Officer) Planned sale (10b5-1) 2,329 $481.79 $1.1M +7.7% 2026-03-17
2026-03-11 McKechnie Duncan (Officer) Planned sale (10b5-1) 2,633 $498.42 $1.3M +4.1% 2026-03-13
2026-03-04 McKechnie Duncan (Officer) Planned sale (10b5-1) 2,437 $475.30 $1.2M +9.2% 2026-03-06
2026-03-02 Liu Joy (Officer) Planned sale (10b5-1) 892 $495.96 $442K +4.7% 2026-03-04
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 120 $481.50 $58K +7.8% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 240 $482.84 $116K +7.5% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 400 $479.75 $192K +8.2% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 460 $489.32 $225K +6.1% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 949 $491.30 $466K +5.6% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 1,725 $496.95 $857K +4.4% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 2,510 $487.13 $1.2M +6.5% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 2,520 $493.29 $1.2M +5.2% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 2,725 $490.54 $1.3M +5.8% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 3,278 $488.27 $1.6M +6.3% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 3,498 $494.33 $1.7M +5% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 5,995 $496.16 $3M +4.6% 2026-03-03
2026-02-27 Kewalramani Reshma (CEO) Planned sale (10b5-1) 15.6K $495.38 $7.7M +4.8% 2026-03-03
2026-02-27 Bozic Carmen (Officer) Planned sale (10b5-1) 2,329 $480.31 $1.1M +8.1% 2026-03-03
2026-02-26 Ambrose Kristen (Officer) Planned sale (10b5-1) 357 $483.36 $173K +7.4% 2026-03-02
2026-02-25 Sachdev Amit (Officer) Planned sale (10b5-1) 1,846 $486.35 $898K +6.7% 2026-02-26
2026-02-25 Biller Jonathan (Officer) Planned sale (10b5-1) 945 $486.35 $460K +6.7% 2026-02-26
2026-02-25 Tatsis Ourania (Officer) Planned sale (10b5-1) 260 $486.35 $126K +6.7% 2026-02-26
2026-02-25 Ambrose Kristen (Officer) Planned sale (10b5-1) 223 $486.35 $108K +6.7% 2026-02-26
2026-02-25 Atkinson Edward Morrow III (Officer) Planned sale (10b5-1) 668 $486.35 $325K +6.7% 2026-02-26
2026-02-25 McKechnie Duncan (Officer) Planned sale (10b5-1) 2,410 $489.00 $1.2M +6.1% 2026-02-26
2026-02-25 McKechnie Duncan (Officer) Planned sale (10b5-1) 2,500 $486.35 $1.2M +6.7% 2026-02-26
2026-02-25 Bunnage Mark E. (Officer) Planned sale (10b5-1) 620 $486.35 $302K +6.7% 2026-02-26
2026-02-19 Sachdev Amit (Officer) Planned sale (10b5-1) 920 $463.91 $427K +11.9% 2026-02-23
2026-02-19 Sachdev Amit (Officer) Planned sale (10b5-1) 1,848 $465.80 $861K +11.4% 2026-02-23
2026-02-19 Sachdev Amit (Officer) Planned sale (10b5-1) 2,730 $465.05 $1.3M +11.6% 2026-02-23
2026-02-19 Sachdev Amit (Officer) Planned sale (10b5-1) 4,237 $471.43 $2M +10.1% 2026-02-23
2026-02-19 Sachdev Amit (Officer) Planned sale (10b5-1) 7,241 $469.61 $3.4M +10.5% 2026-02-23
2026-02-19 Sachdev Amit (Officer) Planned sale (10b5-1) 10.3K $467.75 $4.8M +11% 2026-02-23
2026-02-19 Sachdev Amit (Officer) Planned sale (10b5-1) 11.7K $470.54 $5.5M +10.3% 2026-02-23
2026-02-19 Sachdev Amit (Officer) Planned sale (10b5-1) 19.7K $468.57 $9.2M +10.8% 2026-02-23
2026-02-18 Biller Jonathan (Officer) Planned sale (10b5-1) 1,244 $473.68 $589K +9.6% 2026-02-19
2026-02-18 Tatsis Ourania (Officer) Planned sale (10b5-1) 368 $473.68 $174K +9.6% 2026-02-19
2026-02-18 Ambrose Kristen (Officer) Planned sale (10b5-1) 638 $473.68 $302K +9.6% 2026-02-19
2026-02-18 Atkinson Edward Morrow III (Officer) Planned sale (10b5-1) 817 $473.68 $387K +9.6% 2026-02-19
2026-02-18 Bunnage Mark E. (Officer) Planned sale (10b5-1) 1,182 $473.68 $560K +9.6% 2026-02-19
2026-02-17 Biller Jonathan (Officer) Planned sale (10b5-1) 2,476 $489.46 $1.2M +6% 2026-02-19
2026-02-17 Tatsis Ourania (Officer) Planned sale (10b5-1) 609 $489.46 $298K +6% 2026-02-19
2026-02-17 Ambrose Kristen (Officer) Planned sale (10b5-1) 1,557 $489.46 $762K +6% 2026-02-19
2026-02-17 Atkinson Edward Morrow III (Officer) Planned sale (10b5-1) 2,031 $489.46 $994K +6% 2026-02-19

“Since trade” compares with the latest insider-implied price, not a market quote; this site carries no market data by design.

Filing hygiene

325 Forms 4, 3 years
0 filed late
0 amendments
2.1 avg. days to file

How to read this

A Form 4 transaction code decides everything. P is an open-market purchase and S an open-market sale; those two are the only codes where an insider chose to trade. A is a grant, M an option exercise or vesting, F shares withheld to cover tax, G a gift. Most “insiders dumped billions” headlines are code F and M mechanics.

Sales flagged 10b5-1 run on a plan the insider adopted in advance; since 2023 every Form 4 carries that flag. Buys have historically predicted returns, sales mostly have not, and this page states filings, not advice.

Every number on this page comes from Forms 3, 4 and 5 filed with the SEC, refreshed daily. Browse the source filings on SEC EDGAR. Data through 2026-08-06